Depends on if I'm hunting or target shooting.
Big game for me is deer & hogs, depending on which rifle I'm using 1-3/4" or less 5 shot groups @100yards are fine where I mostly hunt, hell a pistol or slug/00 12ga would work fine also.
If ranges are going to be 300yrds +/-, I'll be using a scoped rifle I worked up load 1-1/4" or less.
target/varmint rifle(s), I'll start mid load & work up in 1/2gr increaments to max load, whichever loading get best grouping from I'll then ladder load +/- .1 loadings see if +/- grouping size and work toward loadings tightening groups, also bullet seating depth +/- for oal to tighten groups.
I use the same brand cases all trimmed same oal & champhered inside/out, weighed (marked & grouped), primer lots same, even have weighed bullets.
Powder I buy in 1lb bottle, if it works for what I'm loading I'll then buy in 8lb jugs from then on.
ETA:
I still use a beam scale & trickler, I throw a slightly lower load into pan with a hornaday manual powder measure/hopper, then trickle up to set weight.